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Head & Neck Squamous Cell |
Pre-Clinical
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STAT3 Therapeutics is developing S3T-001 for Head and Neck Squamous Cell Carcinoma. The drug is currently in the pre-clinical stage. Why?Hyperactivated STAT3 plays an important regulatory role in 95% of all head and neck cancers.1 The STAT3 pathway has the potential to make a significant impact as a therapeutic target. |
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Non-Small Cell Lung Cancer |
Discovery
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STAT3 Therapeutics is developing S3T-002 for Non-Small Cell Lung Cancer. The drug is currently in the discovery stage. Why?Accumulating evidence over the last two decades suggests a critical role for STAT3 as a point of convergence for various signaling pathways that are dysregulated in the disease.2 |
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Glioblastoma |
Discovery
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STAT3 Therapeutics is developing S3T-003 for Glioblastoma. The drug is currently in the discovery stage. Why?Persistent activation of STAT3 induces cell proliferation, anti-apoptosis, glioma stem cell maintenance, tumor invasion, angiogenesis, and immune evasion – making STAT3 an attractive therapeutic target and a prognostic indicator.3 |
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Melanoma |
Discovery
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STAT3 Therapeutics is developing S3T-004 for Melanoma. The drug is currently in the discovery stage. Why?Studies using keratinocyte-specific STAT3-deficient mice have revealed that STAT3 plays an important role in skin homeostasis including keratinocyte migration, wound healing, and hair follicle growth.4 |
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References
- Darnell JE. (2005) Validating Stat3 in cancer therapy. Nat. Med. 11:595–6.
- Role of STAT3 in lung cancer; Pranabananda Dutta, Nafiseh Sabri, Jinghong Li, Willis X Li
JAKSTAT. 2014; 3(4): e999503. Published online 2015 Jan 20. doi: 10.1080/21623996.2014.9996.2014.999503
PMCID: PMC4580090 - The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment; https://www.sciencedirect.com/science/article/pii/S0303720717300047?via%3Dihub
- Everardo Macias, Dharanija Rao, and John DiGiovanni, “Role of Stat3 in Skin Carcinogenesis: Insights Gained from Relevant Mouse Models,” Journal of Skin Cancer, vol. 2013, Article ID 684050, 10 pages, 2013. doi:10.1155/2013/684050